FOXO3 belongs to the O subclass of the forkhead family of transcription factorswhich are characterized by a distinct fork head DNA-binding domain. There are three other […]

Fibroblast growth factor 21 (FGF21) is a hormone-like member of FGF family which controls metabolic multiorgan crosstalk enhancing energy expenditure through glucose and lipid metabolism. In […]

Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be […]

P53 is a crucial tumor suppressor protein that acts as the body’s guardian of the genome. When DNA damage occurs from environmental stresses like radiation or […]

Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins […]

Telomeres, the caps on our chromosomes, shorten with each cell division. This shortening acts like a cellular clock, and critically short telomeres are linked to premature […]

”Senescence is more than merely a cell division clock that regulates the proliferative lifespan of normal cells. “Premature” senescence is an active cytostaticprogram that is triggered […]

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age A hallmark of aging is chronic sterile inflammation, which is closely associated with […]

Oncogene activation plays a critical role in human health and aging, but it’s a double-edged sword. Oncogenes are genes that, when activated, promote uncontrolled cell growth […]