Telomeres, the caps on our chromosomes, shorten with each cell division. This shortening acts like a cellular clock, and critically short telomeres are linked to premature […]

”Senescence is more than merely a cell division clock that regulates the proliferative lifespan of normal cells. “Premature” senescence is an active cytostaticprogram that is triggered […]

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age A hallmark of aging is chronic sterile inflammation, which is closely associated with […]

Oncogene activation plays a critical role in human health and aging, but it’s a double-edged sword. Oncogenes are genes that, when activated, promote uncontrolled cell growth […]

Prevention of premature senescence requires JNK activation. Premature senescence is considered as a cellular defense mechanism to prevent tumorigenesis. Although recent evidences show that c-Jun N-terminal […]

MDM2 antagonists attenuate the senescence-associated secretory phenotype Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells […]

Senescent cells are like retired workers in our bodies. They’ve stopped dividing due to stress or damage, which prevents uncontrolled growth and potential cancer. However, these […]

Apoptosis, also known as programmed cell death, is a crucial process for maintaining human health throughout our lives.It acts as a cellular self-destruct mechanism, eliminating damaged […]

The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates. […]